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How Our Gut Changes Across The Life Course | Eurekalert! Science News

Complex signaling between blood and stem cells controls regeneration in fly gut | EurekAlert! Science News

Chronic low-grade inflammation is seen to increase as we age. "Inflammation is increasingly being seen as a key event behind ageing, and our results suggest a pivotal role for the gut in this 'inflammaging' " process said Prof. Nicoletti. "It is vital we develop ways of controlling inflammaging as a way of preventing bowel cancer, inflammatory bowel disease, heart disease, diabetes and depression" added Professor Watson. Further experiments showed that the increased levels of IL-6 directly lead to making the gut barrier 'leaky' to small, soluble molecules, although no physical differences in its structure were seen.
For the original version including any supplementary images or video, visit http://www.eurekalert.org/pub_releases/2015-05/nbi-hog052115.php

"The temporal sequence of cell interactions during injury-induced regeneration is only beginning to be understood," said Jasper. "The proper timing of these interactions may be key in maintaining a healthy gut." Jasper says aging makes it harder for the stem cells to switch gears between proliferation and quiescence and that flies suffer from age-related intestinal dysfunctions similar to those experienced by humans. Jasper says when the flies are young they are able to fend leaky gut probiotics off what causes leaky gut syndrome infection and repair tissues, but that the cumulative effect of damage over a lifetime takes a toll - signaling goes awry, and stem cells get chronically activated, causing inflammation and dysplasia, which makes the animal more prone to infection and dysfunction. "This is another classic example of 'what is good for us in youth, turns against us with age'," said Jasper. "When we think of interventions, we need to find the sweet spot. We want to promote stem cell repair and regeneration without having those responses become chronically activated." "In this case we have established a role for macrophage - like cells in influencing tissue homeostasis both during infection and during the aging process," said Jasper. "Macrophages are clearly a target for a number of age-related disease - we need to understand their function better.
For the original version including any supplementary images or video, visit http://www.eurekalert.org/pub_releases/2015-05/bifa-csb052115.php

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